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[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Shaw AT et al

These effects could be more pronounced with concomitant use of Hydrocodone Bitartrate and Acetaminophen Tablets and both CYP3A4 and CYP2D6 inhibitors, particularly when an inhibitor is added after a stable dose of Hydrocodone Bitartrate and Acetaminophen Tablets is achieved [see WARNINGS]

It's important to contextualize this concern

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However, there is limited evidence of its use due to the low number of published trials, and it should not be yet disregarded until future studies further assess potential benefits